Focalin and Adderall are both highly regarded medications for treating ADHD. Although they are employed for similar therapeutic purposes, their chemical structures are fundamentally different, which is a crucial aspect of the Focalin versus Adderall comparison. The primary active ingredient in Focalin is dexmethylphenidate, while Adderall is a formulation of various amphetamine salts. Both medications have a significant potential for abuse and can lead to dependency. Adderall IR offers a greater variety of dosage options than Focalin IR, although Focalin IR is generally more affordable.